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Researchers noted that the link between GLP1-RAs and medical benefits was strongest among participants with severe PAD, including chronic limb-threatening ischaemia (CLTI) and those with a body mass index of 30 or higher, which is considered obesity
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As a result, many members turned to diabetes-indicated GLP-1s off-label, creating shortages that impacted patients who needed them for type 2 diabetes
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